Quinolone Antibiotics Have
A Dangerous History
The newer Quinolone Antibiotics are considered 'safe' in most studies, and seem to have a low incidence of side effects. While most problems are the Common Side Effects that plague drugs and placebos alike- taking them with food seems to alleviate many of these problems.
But Quinolone Antibiotics have an VERY DARK history. While the incidence of side effects might be low, some of the people who get them have disabling or devastation long-term effects- and even death from these 'safe' drugs.
"...unexpected adverse reactions, such as
the CNS reaction, the drug-drug interaction,
phototoxicity, hepatotoxicity and cardiotoxicity
such as the QTc interval prolongation of ECG,
have been reported in the clinical evaluations or the
post-marketing surveillance of several new quinolones."
The history of the development and changes
of quinolone antibacterial agents
Notice that they said that these dangerous problems were found 'post-marketing'. This means that these reactions occur AFTER the drug is on the market and is being taken by YOU. What this says is that they KNOW that quinolone antibiotics are dangerous and have side effects that could be disabling or deadly and yet they keep developing new ones in the hope that THIS one won't have those problems.
Quinolone Antibiotics That Have Been
Determined Too Dangerous to Use
This is really NOT an exaggeration. There have been many quinolone antibiotics that have been shown to be safe enough to get FDA approval, yet once released into hospitals and doctor's offices, have been found to have such dangerous side effects that they were removed from the market.
In the case of quinolone antibiotics this has happened not once, not twice, but on at least NINE DIFFERENT OCCASIONS! The quinolone antibiotics that have been found too dangerous to be used by the public AFTER they were already released and being used are:
- Clinafloxacin -Low blood sugar problems and extremely toxic reactions to sunlight
- Grepafloxacin - Prolonged QT Interval leading to deadly heart rhythms in some people
- Sparfloxacin – Extremely toxic reactions to sunlight
- Trovafloxacin - Liver Toxicity
- Temafloxacin – Kidney Failure
- Pefloxacin- Toxic reactions to sunlight, tendon problems
- Fleroxacin- Toxic reactions to sunlight, neurologic problems
- Sitafloxacin- Toxic reactions to sunlight
- Tosufloxacin- Kidney inflammation
- Will the one that you are taking now be next?
Once again, these were drugs that had already been approved for use and were BEING USED BY PEOPLE and had to be removed from further use because of dangerous side effects that were not discovered during the testing period of the drugs.
"Most drug reactions involving these agents
are minor and reversible on discontinuing treatment,
but adverse effects can be associated with significant
mortality and morbidity, as was seen in the case of
trovafloxacin and temafloxacin."
The safety profile of the fluoroquinolones
Tendonitis and Tendon Rupture
Newer quinolone antibiotics are supposed to be safer, and:
- Side Effects of Levaquin
- Ciprofloxacin Side Effects
- Avelox Side Effects
are far fewer than they were in the older drugs- yet they continue to have unexpected disabling side effects such as Levaquin Tendonitis and Achilles Tendon Rupture that surprise the researchers- especially when the large number of Quinolone and Levaquin Drug Interactions are taken into account. For instance, when these drugs are combined with Corticosteroid drugs like Prednisone given for inflammation. The interaction between Levaquin and Prednisone is EXTREMELY serious- yet the combination is given for even minor problems such as Levaquin Sinus Infection treatment- a minor problem that has and could end up leaving a previously healthy 20 year old an invalid with ruptured tendons and lifelong pain.
And these 'newer and safer' drugs, as of July 8th, 2008 now have an FDA Black Box Warning:
"...use of fluoroquinolones is associated
with an increased risk of tendon rupture...
despite the current warning of tendon rupture
in the labeling for the fluoroquinolones,
large numbers of tendon-related adverse events
continue to be reported."
FDA Website Regarding Quinolone Antibiotics and the
Black Box Warning For Tendonitis and Tendon Rupture
So, what the FDA is saying, is that LABELING is not preventing these serious, potentially lifelong disabling side effects that they had already known about. But now they expect a STRONGER warning to prevent these quinolone side effects!?
Remember, these tendon side effects can be disabling AND permanent in some people. Which people? Older people, those taking corticosteroids and those with tendon problems already are MOST at risk, but many people who have been affected had NONE of these problems- and some researchers even speculate that many people with Symptoms of Fibromyalgia may even be due to these drugs. If you are taking Quinolone Antibiotics for NON LIFE-THREATENING conditions like Urinary Tract Infections, Sinus Infections and Travelers Diarrhea- you should decide whether the possibility -however remote- of lifelong disability is worth it.
There is officially no CURE for the tendonitis and toxicity that occurs from the quinolone antibiotics, the authors of this website HAVE developed a Levaquin Tendonitis Solution that is the result of years of research and work with people suffering from this disabling problem.
Quinolone Phototoxicity and
Increased Skin Cancer Risk
As you can see above, many of the quinolones were removed from the market due to toxic reactions to sunlight. Well, with one of the removed drugs, there were almost one thousand REPORTED reactions within the first 8 months after it was put on the market.
These included second-degree burns, discoloration and sometimes permanent discoloration and scarring of the skin. While these problems occur ONLY when the person taking the antibiotics expose themselves to UV light (sunlight or tanning booths),and these antibiotics now DO have warnings on them about going into the sunlight- how many people read the arm's length list of warnings and side effects that comes in the package with these antibiotics?
These skin problems don't stop there,though. In several animal studies, taking these antibiotics and getting exposure to UV light has resulting in a significant increase in skin cancer rates. While increased skin cancer rates have not been found in human studies of quinolone antibiotics (yet), most human studies don't last for the decades that it may take to see the effects that a drug could have on the incidence of any type of cancer.
"The Significance of this finding to the debate of the
possible increased photocarcinogenic risk among
humans taking even a short course of FQ
[fluoroquinolones] has yet to be determined."
Sun Protection in Man
And to top it off, they are now developing TOPICAL quinolone antibiotic CREAMS for the use in cases of acne. Teens and young adults who use these creams are often the MOST likely populations to be sunbathing when given the chance. So, if having teens start using these drugs at a young age for skin conditions that last many years isn't a recipe for increasing skin cancer, then I don't know what is!
Another not so great effect of Quinolone antibiotics is that they pull magnesium from the body. When you read the Signs of Magnesium Deficiency page, you'll see that magnesium deficiency is ALREADY a huge problem in western countries. While HUGE numbers of people are already suffering from undiagnosed magnesium deficiencies, these drugs pull even MORE magnesium from your body in a condition called Magnesium Depletion. And that at a time when you are already sick and using more magnesium!
Some researchers hypothesize that those with depleted magnesium (which is most of us) are MOST at risk for some of the Neurologic Side Effects and Tendon Problems that are occurring with the quinolones. And indeed, there have been a few reports of resolution of these severe problems with the application of topical Transdermal Magnesium Gel that gets absorbed right through the skin.
Quinolone Antibiotics are Simply Toxic
These Quinolones seem to have the term 'toxicity' seems to be sprinkled throughout nearly every research study that has been done on them. So, let's do a review of the types of –toxicities- that have been mentioned, and some that are so severe that the specific drugs have been removed from the market:
- Cardiotoxicity- heart damage and/or Prolonged QT Interval
- Chondrotoxicity- damage to joints and cartilage
- Tendonopathy- damage and rupture of tendons and other connective tissue
- Phototoxicity- Skin damage after exposure to UV light
- Hepatotoxicity- Liver damage
What's the Solution
To Levaquin Tendonitis and Toxicity?
- Neurotoxicity- Nerve and brain problems
- Genotoxic- Damage to DNA and genes
- Nephrotoxicity- Damage to Kidneys
While Quinolone Antibiotics are generally considered 'Safe' by most researchers, with only a small percentage of people experiencing these problems, the researchers and the FDA have been WRONG about the safety of these drugs 9 different times!!
And the people who DO experience these problems can have LIFELONG disabilities, chronic health problems and even increased risk of cancer and sudden death. The fact is that there have just simply been no long-term studies on this class of drugs that includes Cipro and Levaquin that they KNOW have caused major toxic problems to many different organs with a multitude of different formulations with no way of predicting who is going to suffer from these devastating problems. So the question is, are YOU willing to be the next one to be experimented on by taking these antibiotics.
Keep reading to find out what OTHER side effects there are of antibiotics in general...
Antibiotic Side Effects
Have You Had Levaquin Tendonitis
or other Side Effects of Quinolone Antibiotics
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